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Thus, the ENS is regarded as a second brain that can directly or indirectly respond to the microbiota and its metabolites influencing cognitive functions through gut bacteria (51)

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Statins have a proven record of protection from atherosclerotic cardiovascular disease and are extensively used by patients with diabetes [46], hence their potential usefulness in preventing microvascular complications of T2DM has also been tested

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In many patients, these mast cells become locked in a state of chronic hyper-reactivity long after the bacteria are gone, driving systemic inflammation, food intolerances, and migratory pain