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This resulted in the ferroptosis of Leydig cells, testicular dysfunction, and a reduction in sperm quality

For context on SAMe and related evidence limits, see the NIH NCCIH resource S-Adenosyl-L-Methionine (SAMe): In Depth

However, whether these findings translate into a potential therapeutic target by modulating hepatic homocysteine levels remains to be determined in prospective, interventional studies

34 NF-B signaling pathway Nuclear factor-kappa B (NF-B) transcription factors are critical regulators of immunity, stress responses, apoptosis and differentiation