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Serine starvation inhibits the proliferation of colorectal cancer cells in in vitro (Labuschagne et al., 2014

(63) demonstrated that the DIO2 Thr92Ala polymorphism substantially reduces type 2 deiodinase activity, impairs local T4-to-T3 conversion, and is associated with lower serum T3 levels in patients treated with levothyroxine

Recently intriguing findings have emerged that both genetic and epigenetic alterations equally contribute to ESCC with collusion between them, which provides novel theories and understandings about therapeutic effect evaluation, potential therapeutic targets and prognostic prediction in ESCC patients [18]

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