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Thalassemia major patients using iron chelators showed a reduced plasma thioredoxin level and reduced thioredoxin reductase activity, despite elevated oxidative stress
Therefore, displacement of HSA-AFs complexes has been suggested as a therapeutic strategy to diminish the affinity of these mycotoxins to HSA and decrease the tissue delivery and uptake of AFs (177)
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Predominantly, these trials highlighted gastrointestinal adverse events as the most common, including nausea, vomiting, diarrhea, and decreased appetite
