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Improvement is often seen within a few sessions, though the total course varies by severity

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7A) regions in hippocampus of low-dosage of SDUY-225 pretreated SE mice

S100A8 lacks the ability of Ca 2+ -binding in the N-terminal EF-hand motif, due to the absence of Ca 2+ -coordination necessary amino acid residues

Resveratrol, another polyphenol, exhibits anti-inflammatory effects on microglia by inhibiting the NF-B/ERK/JNK MAPK signaling pathway, thereby counteracting the neurotoxicity caused by hypoxia (Zhang et al., 2015), demonstrating neuroprotective effects against hypoxia-induced oxidative stress and apoptosis (Dhar et al., 2019)