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This case highlights the risks of accelerated approvals based on single, modest-sized trials and the imperative for robust phase 3 validation

doi: 10.3389/fmed.2023.1124275 Received 14 December 2022 Accepted 27 February 2023 Published 22 March 2023 Volume 10 - 2023 Edited by Ana Sandoval-Rodriguez, University of Guadalajara, Mexico Reviewed by Angelo Armandi, University of Turin, Italy

UVB radiation can exacerbate pre-existing SLE, however, whether it contributes to SLE disease onset or pathogenesis is less clear

Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

This disequilibrium stops the activity of Na/Ca +2 antiporter membrane protein to pump Ca 2+ out of the cell, causing an intracellular Ca +2 overload (76, 83, 84)