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Data is presented here represents n=1 replicate

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in vitro experiments demonstrated that SGK1 knockdown attenuated erastin-induced downregulation of Slc7a11, GPX4, GSH, and oxidized glutathione (GSSG), while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting SGK1's critical role in CHD-associated ferroptosis ( 3.2.3 Role of lipid peroxidation in coronary heart disease ACSL4, a key upstream regulator of lipid peroxidation, has garnered significant attention for its role in ferroptosis

AUTHOR CONTRIBUTION Zhijie Li: Supervision, Conceptualization, WritingReview & Editing, Funding acquisition

Furthermore, fertility testing of fluoxetine-treated male rats was not performed to directly assess its effects on reproductive function, and the study only employed animal models and did not explore the relevance of the findings for human patients