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Further, substitution of Arg for Sec may not be a random amino acid insertion, as two of the six Arg codons (CGA and AGA) have only a single base difference with the UGA codon

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doi: 10.1007/BF01076518

Opioid receptor sequences lacking a cysteine had little affinity for any of the tested compounds, which was also typical of the insulin receptor sequences tested
There have been no reports of THP use causing dystonia, the dopamineacetylcholine imbalance was suggested as the aetiology that can trigger or exacerbate dystonic movements
