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The researchers found that CJC-1295 was safe and relatively well tolerated when administered at doses of 30 or 60 g/kg, without any notable adverse effects observed

The table lists absolute values and does not include descriptions of multiple cytokines added to regression models

[26] Clinical trials Recombinant protein Several companies have evaluated IGF-1 in clinical trials for a variety of indications, including type 1 diabetes, type 2 diabetes, amyotrophic lateral sclerosis (ALS aka "Lou Gehrig's Disease"), [27] severe burn injury and myotonic muscular dystrophy (MMD)

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The NFB pathway is initiated by the degradation of IB, enabling NF-B to translocate to the nucleus and promote the transcription of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which further damage endothelial cells and disrupt tight junction proteins (Figure 3) [188,189,190]