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Its ubiquitination and degradation can limit the activation of antioxidant genes, thereby reducing the survival and proliferation of cancer cells
doi: 10.1016/J.MSEC.2021.112527

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Antoine Salzmann, Sarah-Naomi James, Dylan M Williams, Marcus Richards, Dorina Cadar, Jonathan M Schott, William Coath, Carole H Sudre, Nishi Chaturvedi, Victoria Garfield, Investigating the Relationship Between IGF-I, IGF-II, and IGFBP-3 Concentrations and Later-Life Cognition and Brain Volume, The Journal of Clinical Endocrinology & Metabolism , Volume 106, Issue 6, June 2021, Pages 16171629