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Karakis et al., 2021

These include patients with impaired renal function due to their inability to adequately clear high IVC doses from circulation, and patients with G6PD deficiency due to inability to detoxify oxidative stress generated by high dose IVC administration

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In addition, alterations of metabolism have been reported in the diabetic brain

doi: 10.1016/j.indcrop.2011.11.008
