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Preclinical doseresponse immunomodulatory research records hormetic doseresponse of numerous phytochemicals: low/moderate dosage can trigger adaptive cytoprotection but higher or chronic dose can cause counterintuitive effect (e.g

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investigated the relationship between the adverse effects of EGCG treatment with dose and administration route by giving EGCG (108, 67.8, 21.1, and 6.6 mg/kg/d) orally or intraperitoneally to mice (230)