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This is one reason the loading schedule is medically supervised rather than something to rush
Bioinformatics 33 , 27742775 (2017)
REL-1017 (esmethadone) as adjunctive treatment in patients with major depressive disorder: a phase 2a randomized double-blind trial
61 Elguindy N, Yacout G, Azab E, Maghtaby H
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