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Human cytosolic glutathione transferases: Structure, function, and drug discovery
Setanaxib, a small molecule NOX4 inhibitor, inhibited ROS generation in TAFs, promoted intratumoral CD8 + T cell infiltration in TAF-rich tumors, therefore repressing tumor growth of TC-1 and MC-38 subcutaneously implanted mice [44, 117]

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As GPX4 plays a critical role in preventing ferroptosis, the CSDS-induced downregulation and EDV-induced upregulation of GPX4 suggest that ferroptosis contributes to depression development

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