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The product of this gene does not directly participate in carotenoid biosynthesis but is involved in chromoplast differentiation, creating a storage site for carotenoids [63]

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Although this technology has not yet reached human clinical trials, several preclinical studies have demonstrated the efficiency of this system to reverse MDR in cancer

Therefore, there is also a need for well-designed disease-specific clinical trials that take into consideration the dietary and genetic determinants of FOCM to clarify the contribution of FOCM to neurodegeneration and to help in the development of targeted therapeutic strategies

Other MR approaches revealed similar estimates in the sensitivity analyses (Supplementary Figure S1), except for negative association with GGT through robust adjusted profile score method (Beta, 0.69