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Much of Noopept cognitive effect may be mediated through its metabolite cycloprolylglycine (cPG), which concentrates preferentially in the hippocampus and has been shown to reduce hippocampal cell death, increase BDNF mRNA, and modulate inflammatory cytokine expression

Changes in GPx expression and activity are closely tied to both metabolism and ER function

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Exp Physiol 82:291295