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Nonetheless, the observation that adolescent alcohol exposure decreases BDNF-AS methylation in the amygdala reveals new mechanisms of RNA regulation that add another layer of complexity of epigenetic regulation of BDNF expression in AUD

Additionally, the specific pathogenic mechanisms of the altered strains have not yet been clearly established

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As noted by Kraus et al., Nature Medicine , NNMT inhibition in white adipose tissue significantly increased energy expenditure and reduced fat mass in animal models without changes to diet or activity