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If a patient has specific or red flag features B 12 deficiency testing should be initiated (see Figure 1: B 12 Test Result Review and Process Algorithm for Patients with Risk Factor for B 12 Deficiency * and/or Non-specific ** or Specific Symptom of B 12 Deficiency )

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2015 NNMT consumes SAM as a methyl donor, competing with DNA and histone methyltransferases