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In line with these findings, prior work showed that E2 heightens the inflammatory response to ip injection of thioglycollate or lipopolysaccharide (291), and that ER is critical not only in mediating these actions but also for reducing bacterial burden through phagocytosis

doi: 10.1016/j.euroneuro.2006.08.005 78

The Journal of clinical investigation 123 , 43094317, doi:10.1172/JCI64801 (2013)

Importantly, early studies suggest that therapeutic strategies aimed at increasing mitochondrial proteolysis or reprogramming microglial phenotypes could attenuate this cycle

Pharm Res 2016;33(3):590602
