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32 There is early lethality in complete SOD2 / knockout mice, but the effects of antioxidant dysfunction have been shown in SOD2 +/ mice experiments, where animals with low antioxidant capacity experienced direct damage to lipids, proteins and DNA, though OS also caused behavioural impairments as well as increased OS makers in the hypothalamus and cortex

this finding may indicate that ascorbate can also function as an allosteric modulator of the OPR, which would be consistent with the fact that it shares some common structural binding motifs with opioid compounds [66,67,68] as well as shared GPCR enhancement [49,50,51,52,58,59,60,61,62,63,65,69,70,71,72,73,74,75,76,77]

doi: 10.1517/17425247.2011.574121

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7cf), suggesting that NLRP3 may affect the calcification-associated transcription factor RUNX2
