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Abstract: Introduction: Peptides are promising and attractive anti-wrinkle active ingredients, amongst which glycyl-histidyl-lysine peptide (GHK) is one of the most broadly promoted peptide for topical application

Based on the above, in this study, we aimed to investigate whether Dihexa improves the cognition of APP/PS1 mice and whether the brain AngIV/PI3K/AKT axis is a possible mechanism

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