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Liver tissue from Gclc L-KO mice showed enrichment of NRF2 protein and downstream target genes (Fig

AGNP-mediated inhibition of NF- was also meaningfully higher compared to free-AG

2019 Annual Meeting of The American Society of Hematology

To validate SLC7A11 as the target by which LDHB negatively regulates ferroptosis, we overexpressed SLC7A11 in A549 and H838 cells in which LDHB was stably knocked down by shRNAs ( Supplementary Figure 7a )

The other injuries were initiated at periphery (i.e., nerve transection [79], abdominal aorta occlusion [82], tumor cachexia [11], or application of neurotoxin [69,80], distinctive muscle relaxants [81], neuroleptics [68,70], L-arginine [86], L-NAME [70,86], alcohol acute and chronic intoxication [63,64], and electrolytes disturbances [54,83,84,85])
