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A six-month, double-blind, multicenter experiment using oral L-Lysine monohydrochloride showed that the lysine treatment group averaged 2.4 times fewer HSV outbreaks, with significantly diminished symptoms and shorter healing times (during the research period) than the placebo group

This is a key variable to consider in experimental design

The addition of B12 addresses this metabolic shift directly
Mar;1778(3):588600
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