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A., Bouvier J

Homozygous mutations may result in more significant disruptions in methylation

Some of the detrimental effects of homocysteine are due to its binding to lysyl oxidase, an enzyme responsible for proper maturation of the extracellular matrix proteins collagen and elastin

Long-Term Safety Considerations While 24-week human trials provide reassurance about short-to-medium term safety, very long-term data (multi-year continuous use) is limited

[DOI] [PubMed] [Google Scholar] 21.Gautron L, Elmquist JK
