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This might be one reason for the decreased efficiency of vaccination in the elderly, who are known to be at least marginally zinc deficient in most cases [215,216]

Due to the close proximity of the ER to mitochondria, localized high concentrations of Ca2+ promote mitochondrial uptake, inducing conformational changes in regulatory factors like mitochondrial Ca2+ uptake proteins and enhancing cell motility, which supports cell migration (31,120)

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Sawaya ME, Price VH

Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: synthesis, preparation and in vivo evaluation