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Experimental observations suggested that dual-loaded chitosan nanoparticles exhibited greater anti-proliferative activity against MCF-7 cells than doxorubicin-loaded chitosan nanoparticles alone
Cancer-cell metabolism studies NNMT is overexpressed in several cancer cell lines, and 5-Amino-1MQ has been used in vitro to characterise its role in tumour metabolism
Preclinical work in obese murine models suggests that encapsulated 5-Amino-1MQ administration led to decreases in overall body weight and reductions in white adipose mass
[DOI] [PubMed] [Google Scholar] 118.Matson CA, Reid DF, Ritter RC
