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Results from earlier clinical trials of oral GSH supplementation have been contrasting and debatable

The ideal treatment should be able to target all the issues of this pathology: increased inflammatory parameters, lipid accumulation, and oxidative stress generation

JAMA Intern Med 179(5):633640

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Six were depleted in the frail brain, including cytoskeletal proteoforms derived from MAP2, -tubulin and vimentin, whilst 16 were increased with cognitive frailty, including CHGA/B, CCK and other cytoskeletal peptides such as -tubulin and PALM (Fig