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Subtypes 1a and 1b are found worldwide and cause 60% of all cases

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3 Invasion and metastasis 3.1 Ang II/AT1R/CaM signal Angiotensin II (Ang II), angiotensin II type 1 receptor (AT1R) and calmodulin (CaM) are important bioactive molecules that affect the formation and prognosis of HCC