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Description
Cell death assays for drug discovery

Considering the relatively high concentrations of NADH and NAD + in the mitochondrial matrix, most of which exist in their free forms [54], it is questionable whether complex I serves as the primary source of ROS generation within mitochondria under physiological conditions

doi: 10.3390/ph203134

Further testing of antioxidative agents on these models would help to evaluate the safety and effectiveness of such treatment

10.1038/ng.186 181
