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Islets isolated from WT and GCGR-KO mice were loaded with the cytoplasmic Ca 2+ indicator Fluo-4 AM, and cytoplasmic Ca 2+ concentration responses to stimulation were recorded by confocal time-lapse imaging (Fig

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When applying the treatment-regimen estimand2, people treated with CagriSema 2.4 mg/2.4 mg achieved a weight loss of 20.2% compared to 23.6% with tirzepatide at 84 weeks

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