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The activation of AMPK promotes the clearance of misfolded proteins such as -synuclein and supports the function of mitochondria by stimulating peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1, a regulator of biogenesis of mitochondria)

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Additionally, it protects the energy-producing enzymes from attack by nitric oxide, promoting, and sustaining energy production

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