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(Nanjing, China) and housed in a specific-pathogen-free facility under standard conditions

Research has shown that higher doses don't offer much more benefit

47,75,76,77 Recently, we reported that GH promotes radioresistance in cancer cell lines 78 and that pegvisomant suppresses endometrial tumor regrowth following radiotherapy in a xenograft model, which highlights the potential utility of this combinational approach and identifies GHR antagonism as a potential molecularly targeted radiosensitizing strategy

Based on our clinical experience, these changes often develop gradually and usually reach their peak within 36 months after treatment

A., Lpez-Briones, S