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Intramuscular Vitamin D3 injections may be recommended when oral supplements are ineffective or unsuitable, including: Malabsorption disorders: Such as celiac disease, Crohns disease, or ulcerative colitis

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We and others reported that the loss of OL in AD brain can be recapitulated in distinct transgenic mouse models carrying single ( APP (9)), double ( APP , PSEN1 (10)) and triple ( APP , PSEN1 , MAPT (1113)) genetic mutations associated with the amyloid cascade hypothesis