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atlantica ), contains many key components, including procyanidins, ferulic acid, taxifolin, catechin, and caffeic acid ( Chronic inflammation and oxidative stress are central contributors to the pathogenesis of numerous diseases, including type 2 diabetes, cardiovascular diseases, and various liver conditions ( In clinical and experimental settings, PYC reduces the cardiovascular risk in patients with type 2 diabetes ( Furthermore, PYC modulates inflammatory gene expression in human leukocytes by inhibiting 5-lipoxygenase and cyclooxygenase (COX)-2, with a compensatory upregulation of COX-1 gene expression ( In addition to its anti-inflammatory and antioxidant effects, PYC demonstrates diverse therapeutic effects

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In summary, neuroprotective capacity is a major differentiator: natural compounds engage pathways (antioxidant responses, antiapoptosis, protein homeostasis, etc.) that maintain neuron health, whereas levodopa largely bypasses these diseasemodifying mechanisms (Figure 5)