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When exposed to oxidizing stimuli, KEAP1s cysteine residues are bound by ROS, changing the proteins structure

Yes, when administered by licensed medical professionals in a clinical setting, intravenous therapy is generally safe
Pharmacol Res 2021

25 EntringerS.WadhwaP

After the drugs enter the cells through endocytosis, the toxic payload is released inside the cells through the action of lysosomes and subsequently exerts cell-killing effects 88
