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Through mechanisms such as inhibition of drug efflux pumps, modulation of metabolic pathways, regulation of miRNAs, and manipulation of key signaling pathways, UA sensitizes cancer cells to drugs like adriamycin, cisplatin, paclitaxel, and sorafenib

Total lignans from Schisandra increase the activity of the NADK/NADPH/GSH system to reduce A deposition (114) and schisandrin B downregulates glycogen synthase kinase 3 (GSK3) expression to promote NRF2/GPX4 signaling (115)