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Furthermore, obesity and metabolic syndrome (MetS) also appear to be risk factors for the occurrence of PD through the same mechanism, namely systemic inflammation, insulin and leptin resistance, blood-brain barrier disruption, and altered brain metabolism (Neto et al., 2023

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Lee KH, Cha M, Lee BH (2020) Neuroprotective effect of antioxidants in the brain

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Although GLO1 is reported to be higher expressed in a number of different cancer types including the lung 37,52,53 , in our cohort of 70 patients we did not observe such a clear trend: almost half of the patients had a higher and the other half a lower GLO1 protein expression in tumor compared to the surrounding healthy tissue (Fig
