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J.DuanM.ZhouC.JiaoJ.ChengP.YangL.et al

demonstrated that lactate acts as a signaling molecule in endothelial cells by inducing HIF-1 activation and promoting tumor angiogenesis

45 demonstrated that there were numerous vacuoles in the hepatocytes of the rabbits fed the HCD, according to an investigation of the liver's histology

It is intended for use in clinical settings where oral administration is not feasible or where higher plasma concentrations are desired, such as in cases of severe deficiency, certain infections, or as adjunctive therapy in specific medical protocols

Of particular note is the presence of the protein HNRNPA1 (Heterogeneous nuclear ribonucleoprotein A1) in the network, a key RNA-binding protein that regulates the alternative splicing of PKM pre-mRNA, thereby favoring the formation of PKM2 mRNA over that of PKM1 41,42