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PSA that enters the circulation intact is rapidly bound by protease inhibitors, primarily alpha 1-antichymotrypsin, although a fraction is inactivated in the lumen by proteolysis and circulates as free PSA

This system allows a higher proportion of di- and tripeptides to escape hydrolysis and metabolisation be the enterocytes, and hence are more efficiently transported into the bloodstream and other tissues, such as the liver, immune system, kidneys and skeletal muscles

Then, collagenase resistant 7S dodecamers are extracted and purified by ion exchange and gel filtration chromatography

1 (download XLSX Statistical source data for Extended Data Fig

SLC38A2, a sodium-coupled neutral amino acid transporter, is highly expressed in DCs