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Data Availability All data and information used in the preparation of this review article are cited in the references and are accessible to readers (open access)

Reducing the ratio from 25:1 to 5:1 enhanced T- and B-cell responsiveness, increased production of Prostaglandin E3 without affecting pro-inflammatory cytokines or Prostaglandin E2, and lowered MDA levels in older dogs, indicating reduced lipid peroxidation