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Like many regulator proteins, HIF-1alpha is relatively short-lived

An alternative proposal was made by Cheng et al

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Accordingly, glycolysis is required to sustain YAP/TAZ pro-tumorigenic functions, and YAP/TAZ is required for the full deployment of glucose growth-promoting activity ( Travelers: The Metabolism of Deadherent Cells The dissemination of transformed cells is an integral characteristic of cancers, but it is absent from benign growths

As for tauopathy models, increased aggressive or agitative-like behavior has been associated with the progression of tau pathology (Jul et al., 2015