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In contrast to dendritic cells, M2-type macrophages with high levels of CH25H are enriched in immunosuppressive tumor microenvironments and are associated with reduced survival rates in several types of cancer

doi:10.1590/S0100-879X2003000200002

In addition, artesunate inhibits PF by regulating the expression of the profibrotic proteins, type IV collagen, TIMP-1/2, MMP-2/9, TGF-1, Smad3, HSP47, -SMA, and type I collagen (Wang et al., 2016

Ranke MB, Savage MO, Chatelain PG, Preece MA, Rosenfeld RG, Blum WF, Wilton P: Insulin-like growth factor I improves height in growth hormone insensitivity: two years results

Conversely, blocking the CB1 receptor with the anti-obesity drug Rimonabant led to reductions in obesity, inflammatory cytokines, and certain gut bacterial strains [14]