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Thus, MP exposure indirectly contributes to these metabolic disorders by fostering an inflammatory environment and disrupting metabolic regulation

I think those are all big signals that we need some type of hypoxic stress

Considering this enforced lipogenesis, an argument against -oxidation in solid tumors is substantiated by the reductive stress of the cancer cell interior

Garg R, Garcia-Manero G, Faderl S, Cortes J, Koller C, Beran M, Borthakur G , Kantarjian H, Ravandi F

Other AEs that lead to immediate cessation of the KD were severe lethargy, which occurred after 5 months of KD in one case [39] and lactic acidosis (after 5 days of KD) in one other case [36]