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These include poor dietary habits, life-stages and/or lifestyles either limiting intakes or increasing micronutrient requirements (e.g., smoking and alcohol or drug abuse), various diseases, exposure to pollutants and smoke (both active and passive), and economic reasons (poor socioeconomic status and limited access to nutritious food) [15,16]

Mortality outcomes after busulfan-containing conditioning treatment and haemopoietic cell transplantation in patients with Gilberts syndrome: a retrospective cohort study

Diversity and complexity of cell death: a historical review

In other words, long-term calorie restriction doesnt appear to directly reduce serum IGF-1 in humans (18)

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