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Older individuals may benefit more from supplementation and potentially tolerate higher doses well

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A significant down-regulation of several other enzymes related to energy metabolism was also confirmed at the protein level in riboflavin deficient cells, such as DLD, SDHA, NDUFS1, and NDUFV2

S., et al., Lysyl Oxidase Induces Vascular Oxidative Stress and Contributes to Arterial Stiffness and Abnormal Elastin Structure in Hypertension: Role of p38MAPK, Antioxidants & Redox Signaling 27, no