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88 Setmelanotide can result in skin tanning, with darkening of the lips and naevi, and occasional hair colour darkening in patients who are POMC deficient and LEPR deficient

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Derived from the UCSC Genome Browser using the Comparative Genomics track to examine alignments and evolutionary conservation of vertebrate LIPI gene sequences

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Clinically insignificant in healthy individuals but potentially relevant in uncontrolled hypertension

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In a study of over 800 families with melanoma from southern Europe, 3.8% of families who tested negative for CDKN2A and CDK4 pathogenic variants carried POT1 variants.[48] Nine of 14 families had POT1 Ser270Asn variants

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Do not take deferasirox with aluminum-containing antacid products [see Drug Interactions (7.1)]

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