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Protection against oxidative damage and cell death by the natural antioxidant ergothioneine

PMID 9501533

Mitochondria produce large amounts of ROS through the oxidation-reduction reactions carried out in the respiratory chain.2 Evidence indicates that under physiological conditions, ROS may participate in redox signalling, but excessive ROS production may cause oxidative damage to proteins, lipids and DNA, and affect cellular functionality.3 Several studies indicate the role of oxidative stress in the progression of autoimmune thyroid diseases, such as Graves disease.4 ROS are neutralised by the antioxidant enzymes SOD, CAT, and GPx

In this study, we use the latest developments in the differential scanning fluorimetry guided refolding approach as an analytical method to detect correctly refolded protein

Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment