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For instance, in vitro Fluvastatin impairs HCV genome replication through the downregulation of CLDN-1 protein implicated in cell entry and in combination with IFN treatment its effect is potentialized.84 In contracts, pravastatin showed a proviral effect by upregulation the transcription of LDLR, then favoring HCV infectivity.85,86 All those findings suggest that modulation of metabolic machinery, specifically cholesterol pathways, could be a reliable strategy to attack HCV infection

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