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Nevertheless, in the past few years, seven randomized phase III clinical trials, which tested other first-line and second-line treatments, in intermediate-stage or advanced-stage HCC patients have not found any obvious OS benefits (Llovet et al., 2015)

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This can lead to: Tolerance (needing more to feel the same effects) Dependence (difficulty functioning without the drug) Compulsive use despite negative consequences Clinically, stimulant use disorder is diagnosed when substance use leads to significant impairment or distressoften including cravings, failed attempts to quit, and continued use despite harm