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CNS Drugs 15 , 287310 (2001) Thornalley, P

found that a substance called dehydroabietic acid binds to Keap1, activates NRF2-ARE, induces downstream gene expression, which in turn upregulates GSH, GPX4, inhibits ROS accumulation and lipid peroxidation, suppresses ferroptosis and NAFLD [148]

Chen, C., Yang, Z

Quercetin and epigallocatechin gallate (EGCG) are other widely studied polyphenols that protect against oxidative damage through redox modulation of the NRF2 pathway
High insulin levels suppress IGF binding protein (BP)-1 resulting in a relative increase in free IGF-I levels